Details for Accession #: Q9NYV4

Protein Sequence

>sp|Q9NYV4|CDK12_HUMAN Cyclin-dependent kinase 12 OS=Homo sapiens OX=9606 GN=CDK12 PE=1 SV=2
MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEA
ASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSR
DLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLH
KEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGA
SYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQR
SVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSP
AYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKES
KGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGK
VKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLP
TTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQAN
SQPPVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQ
RTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWG
KRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQ
LIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFM
KQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLW
YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVW
PDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFL
KDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVK
NSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNI
HSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEAS
STPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHIL
PPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEH
QALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSL
SHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNY
GELGPGTTGASSSGAGLHWGGPTQSSAYGKLYRGPTRVPPRGGRGRGVPY

Peptide Information

ID Peptide Seq Site Residue Position in Peptide Position in Protein
891 TSAVSSQANSQPPVQVSVK S 17 608.0
5082 TSAVSSQANSQPPVQVSVK T 592.0
5083 TSAVSSQANSQPPVQVSVK S 593.0
5084 TSAVSSQANSQPPVQVSVK S 597.0
5085 TSAVSSQANSQPPVQVSVK S 601.0
5086 TSAVSSQANSQPPVQVSVK S 608.0
11311 TSAVSSQANSQPPVQVSVK
10000777 TSAVSSQANSQPPVQVSVK S 6 597
10000807 TSAVSSQANSQPPVQVSVK T 1 592
10003403 VPASSTSTL S 4 579
10004230 TSAVSSQANSQPPVQVSVK S 10 601
10006452 PASSTSTLPPSTHSKTSAVSSQANSQPPVQV T 592
10008522 SLSRSPLPSRK S 349
10008523 TSAVSSQANSQPPVQVSVK S 593
10008524 TSAVSSQANSQPPVQVSVK T 592
10009704 TSAVSSQANSQPPVQVSVK T 1 592
10009705 TSAVSSQANSQPPVQVSVK S 2 593
10009706 TSAVSSQANSQPPVQVSVK S 5 596
10009707 TSAVSSQANSQPPVQVSVK S 6 597
10011349 LQNYGELGPGTTGASSSGAGLHWGGPTQSSAYGK T 12 1448
10011614 TSAVSSQANSQPPVQVSVK T 1 592
10011615 TSAVSSQANSQPPVQVSVK S 17 608
10011616 TSAVSSQANSQPPVQVSVK S 2 593
10011617 TSAVSSQANSQPPVQVSVK S 10 601
10015886 TSAVSSQANSQPPVQVSVK T 1 592
10015887 TSAVSSQANSQPPVQVSVK S 6 597
10017698 TSAVSSQANSQPPVQVSVK S 2 593
10017699 TSAVSSQANSQPPVQVSVK S 5 596
10017700 TSAVSSQANSQPPVQVSVK S 6 597
10018857 593
10018858 592
10019234 597
10019341 1363
10020216 301
10020242 303
10021860 593
10021899 1363
10021941 597
10023239 TSAVSSQANSQPPVQVSVK S 3 593
10023341 TSAVSSQANSQPPVQVSVK S 6 596
10023453 TSAVSSQANSQPPVQVSVK S 11 601
10023463 LQNYGELGPGTTGASSSGAGLHWGGPTQSSAYGK T 12 1447
10023503 LQNYGELGPGTTGASSSGAGLHWGGPTQSSAYGK S 16 1451
10023520 LQNYGELGPGTTGASSSGAGLHWGGPTQSSAYGK S 18 1453
10023522 TSAVSSQANSQPPVQVSVK S 18 608
10023553 LQNYGELGPGTTGASSSGAGLHWGGPTQSSAYGK S 30 1465
10024545 1447
10024546 592
10024547 1363
10025323 TSAVSSQANSQPPVQVSVK T 1 592
10025324 TSAVSSQANSQPPVQVSVK S 2 593
10025325 TSAVSSQANSQPPVQVSVK S 6 597
10025526 TSAVSSQANSQPPVQVSVK T 592
10025527 TSAVSSQANSQPPVQVSVK S 608
10025528 TSAVSSQANSQPPVQVSVK S 593
10025529 TSAVSSQANSQPPVQVSVK S 601
10026438 TSAVSSQANSQPPVQVSVK S 10 601
10026439 TSAVSSQANSQPPVQVSVK S 6 597
10026703 TSAVSSQANSQPPVQVSVK S 2 593
10026704 TSAVSSQANSQPPVQVSVK T 1 592
10028276 TSAVSSQANSQPPVQVSVK S 6 597
10028462 TSAVSSQANSQPPVQVSVK S 5 596
10028463 NSGPALTESLVQTLVK T 7 1363
10028464 LQNYGELGPGTTGASSSGAGLHWGGPTQSSAYGK T 12 1448
10029767 TSAVSSQANSQPPVQVSVK T 1 592
10029768 TSAVSSQANSQPPVQVSVK S 2 593
10029769 TSAVSSQANSQPPVQVSVK S 6 597
10029770 LQNYGELGPGTTGASSSGAGLHWGGPTQSSAYGK T 11 1447
10030047 NSGPALTESLVQTLVK T 7 1363
10030827 TSAVSSQANSQPPVQVSVK T 1 592
10030828 TSAVSSQANSQPPVQVSVK S 2 593
10030829 TSAVSSQANSQPPVQVSVK S 6 597
10031196 NSGPALTESLVQTLVK T 7 1363
10031197 LQNYGELGPGTTGASSSGAGLHWGGPTQSSAYGK T 11 1447
10031999 T 1447
10032000 T 592
10032001 T 1363
10032511 TSAVSSQANSQPPVQVSVK S 10 601
10032512 TSAVSSQANSQPPVQVSVK S 2 593
10032782 TSAVSSQANSQPPVQVSVK S 5 596
10032879 TSAVSSQANSQPPVQVSVK S 6 597
10033531 TSAVSSQANSQPPVQVSVK T 1 592
10033532 LQNYGELGPGTTGASSSGAGLHWGGPTQSSAYGK S 30 1466
10034512 LQNYGELGPGTTGASSSGAGLHWGGPTQSSAYGK T 1448
10034513 TSAVSSQANSQPPVQVSVK T 592
10034921 TSAVSSQANSQPPVQVSVK S 6 597
10034922 TSAVSSQANSQPPVQVSVK S 10 601
10035090 TSAVSSQANSQPPVQVSVK S 10 601

O-GlcNAcylation Information

ID Method Analytical Throughput Ambiguity Species Sample Type Data Source PMID Comments
891 MS HTP None human HeLa cells 22661428 None
5082 MS HTP None human T cells 29351928 None
5083 MS HTP None human T cells 29351928 None
5084 MS HTP None human T cells 29351928 None
5085 MS HTP None human T cells 29351928 None
5086 MS HTP None human T cells 29351928 None
11311 MS HTP None human HeLa cells 30379171 None
10000777 MS HTP None human HeLa cells 20068230 None
10000807 MS HTP None human HeLa cells 20068230 None
10003403 MS HTP None human leukemia cells 28314751 None
10004230 MS HTP None human HEK 293T cells 29249144 None
10006452 MS HTP None human HeLa cells 30059200 None
10008522 MS HTP None human HeLa cells 30379171 None
10008523 MS HTP None human HeLa cells 30379171 None
10008524 MS HTP None human HeLa cells 30379171 None
10009704 MS HTP None human HEK 293T cells 30620550 None
10009705 MS HTP None human HEK 293T cells 30620550 None
10009706 MS HTP None human HEK 293T cells 30620550 None
10009707 MS HTP None human HEK 293T cells 30620550 None
10011349 MS HTP None human HeLa cells 31492838 None
10011614 MS HTP None human liver 31637018 None
10011615 MS HTP None human liver 31637018 None
10011616 MS HTP None human liver 31637018 None
10011617 MS HTP None human liver 31637018 None
10015886 MS HTP None human HeLa cells 20068230 None
10015887 MS HTP None human HeLa cells 20068230 None
10017698 MS HTP None human HEK 293T cells 30620550 None
10017699 MS HTP None human HEK 293T cells 30620550 None
10017700 MS HTP None human HEK 293T cells 30620550 None
10018857 MS HTP None human HeLa cells 34161081 None
10018858 MS HTP None human HeLa cells 34161081 None
10019234 MS HTP None human HeLa cells 34161081 None
10019341 MS HTP None human HeLa cells 34161081 None
10020216 MS HTP None human HeLa cells 34161081 None
10020242 MS HTP None human HeLa cells 34161081 None
10021860 MS HTP None human HeLa cells 34161081 None
10021899 MS HTP None human HeLa cells 34161081 None
10021941 MS HTP None human HeLa cells 34161081 None
10023239 MS HTP None human HeLa cells 34846842 None
10023341 MS HTP None human HeLa cells 34846842 None
10023453 MS HTP None human HeLa cells 34846842 None
10023463 MS HTP None human HeLa cells 34846842 None
10023503 MS HTP None human HeLa cells 34846842 None
10023520 MS HTP None human HeLa cells 34846842 None
10023522 MS HTP None human HeLa cells 34846842 None
10023553 MS HTP None human HeLa cells 34846842 None
10024545 MS HTP None human colorectal cancer (CRC) cell lines 35254053 None
10024546 MS HTP None human colorectal cancer (CRC) cell lines 35254053 None
10024547 MS HTP None human colorectal cancer (CRC) cell lines 35254053 None
10025323 MS HTP None human THP1 cells 32938750 None
10025324 MS HTP None human THP1 cells 32938750 None
10025325 MS HTP None human THP1 cells 32938750 None
10025526 MS HTP None human liver 31637018 None
10025527 MS HTP None human liver 31637018 None
10025528 MS HTP None human liver 31637018 None
10025529 MS HTP None human liver 31637018 None
10026438 MS HTP None human Jurkat cells, MCF-7 cells, K562 cells 35132862 None
10026439 MS HTP None human Jurkat cells, MCF-7 cells, K562 cells 35132862 None
10026703 MS HTP None human HeLa cells 35254053 None
10026704 MS HTP None human HeLa cells 35254053 None
10028276 MS HTP None human HeLa cells 35254053 None
10028462 MS HTP None human HeLa cells 35254053 None
10028463 MS HTP None human HeLa cells 35254053 None
10028464 MS HTP None human HeLa cells 35254053 None
10029767 MS HTP None human SW480 cells 35254053 None
10029768 MS HTP None human SW480 cells 35254053 None
10029769 MS HTP None human SW480 cells 35254053 None
10029770 MS HTP None human SW480 cells 35254053 None
10030047 MS HTP None human SW480 cells 35254053 None
10030827 MS HTP None human SW620 cells 35254053 None
10030828 MS HTP None human SW620 cells 35254053 None
10030829 MS HTP None human SW620 cells 35254053 None
10031196 MS HTP None human SW620 cells 35254053 None
10031197 MS HTP None human SW620 cells 35254053 None
10031999 MS HTP None human SW480 cells, SW620 cells 35254053 None
10032000 MS HTP None human SW480 cells, SW620 cells 35254053 None
10032001 MS HTP None human SW480 cells, SW620 cells 35254053 None
10032511 MS HTP None human HeLa cell nucleus 35289036 None
10032512 MS HTP None human HeLa cell nucleus 35289036 None
10032782 MS HTP None human HeLa cell nucleus 35289036 None
10032879 MS HTP None human HeLa cell nucleus 35289036 None
10033531 MS HTP None human HeLa cell nucleus 35289036 None
10033532 MS HTP None human HeLa cell nucleus 35289036 None
10034512 MS HTP None human MCF-7 cells 35513511 None
10034513 MS HTP None human MCF-7 cells 35513511 None
10034921 MS HTP None human Jurkat cells 35705054 None
10034922 MS HTP None human Jurkat cells 35705054 None
10035090 MS HTP None human Jurkat cells 35705054 None
ID Peptide Seq Site Residue Position in Peptide Position in Protein Method Analytical Throughput Ambiguity Species Sample Type Data Source PMID Comments
891 TSAVSSQANSQPPVQVSVK S 17 608.0 MS HTP None human HeLa cells 22661428 None
5082 TSAVSSQANSQPPVQVSVK T 592.0 MS HTP None human T cells 29351928 None
5083 TSAVSSQANSQPPVQVSVK S 593.0 MS HTP None human T cells 29351928 None
5084 TSAVSSQANSQPPVQVSVK S 597.0 MS HTP None human T cells 29351928 None
5085 TSAVSSQANSQPPVQVSVK S 601.0 MS HTP None human T cells 29351928 None
5086 TSAVSSQANSQPPVQVSVK S 608.0 MS HTP None human T cells 29351928 None
11311 TSAVSSQANSQPPVQVSVK MS HTP None human HeLa cells 30379171 None
10000777 TSAVSSQANSQPPVQVSVK S 6 597 MS HTP None human HeLa cells 20068230 None
10000807 TSAVSSQANSQPPVQVSVK T 1 592 MS HTP None human HeLa cells 20068230 None
10003403 VPASSTSTL S 4 579 MS HTP None human leukemia cells 28314751 None
10004230 TSAVSSQANSQPPVQVSVK S 10 601 MS HTP None human HEK 293T cells 29249144 None
10006452 PASSTSTLPPSTHSKTSAVSSQANSQPPVQV T 592 MS HTP None human HeLa cells 30059200 None
10008522 SLSRSPLPSRK S 349 MS HTP None human HeLa cells 30379171 None
10008523 TSAVSSQANSQPPVQVSVK S 593 MS HTP None human HeLa cells 30379171 None
10008524 TSAVSSQANSQPPVQVSVK T 592 MS HTP None human HeLa cells 30379171 None
10009704 TSAVSSQANSQPPVQVSVK T 1 592 MS HTP None human HEK 293T cells 30620550 None
10009705 TSAVSSQANSQPPVQVSVK S 2 593 MS HTP None human HEK 293T cells 30620550 None
10009706 TSAVSSQANSQPPVQVSVK S 5 596 MS HTP None human HEK 293T cells 30620550 None
10009707 TSAVSSQANSQPPVQVSVK S 6 597 MS HTP None human HEK 293T cells 30620550 None
10011349 LQNYGELGPGTTGASSSGAGLHWGGPTQSSAYGK T 12 1448 MS HTP None human HeLa cells 31492838 None
10011614 TSAVSSQANSQPPVQVSVK T 1 592 MS HTP None human liver 31637018 None
10011615 TSAVSSQANSQPPVQVSVK S 17 608 MS HTP None human liver 31637018 None
10011616 TSAVSSQANSQPPVQVSVK S 2 593 MS HTP None human liver 31637018 None
10011617 TSAVSSQANSQPPVQVSVK S 10 601 MS HTP None human liver 31637018 None
10015886 TSAVSSQANSQPPVQVSVK T 1 592 MS HTP None human HeLa cells 20068230 None
10015887 TSAVSSQANSQPPVQVSVK S 6 597 MS HTP None human HeLa cells 20068230 None
10017698 TSAVSSQANSQPPVQVSVK S 2 593 MS HTP None human HEK 293T cells 30620550 None
10017699 TSAVSSQANSQPPVQVSVK S 5 596 MS HTP None human HEK 293T cells 30620550 None
10017700 TSAVSSQANSQPPVQVSVK S 6 597 MS HTP None human HEK 293T cells 30620550 None
10018857 593 MS HTP None human HeLa cells 34161081 None
10018858 592 MS HTP None human HeLa cells 34161081 None
10019234 597 MS HTP None human HeLa cells 34161081 None
10019341 1363 MS HTP None human HeLa cells 34161081 None
10020216 301 MS HTP None human HeLa cells 34161081 None
10020242 303 MS HTP None human HeLa cells 34161081 None
10021860 593 MS HTP None human HeLa cells 34161081 None
10021899 1363 MS HTP None human HeLa cells 34161081 None
10021941 597 MS HTP None human HeLa cells 34161081 None
10023239 TSAVSSQANSQPPVQVSVK S 3 593 MS HTP None human HeLa cells 34846842 None
10023341 TSAVSSQANSQPPVQVSVK S 6 596 MS HTP None human HeLa cells 34846842 None
10023453 TSAVSSQANSQPPVQVSVK S 11 601 MS HTP None human HeLa cells 34846842 None
10023463 LQNYGELGPGTTGASSSGAGLHWGGPTQSSAYGK T 12 1447 MS HTP None human HeLa cells 34846842 None
10023503 LQNYGELGPGTTGASSSGAGLHWGGPTQSSAYGK S 16 1451 MS HTP None human HeLa cells 34846842 None
10023520 LQNYGELGPGTTGASSSGAGLHWGGPTQSSAYGK S 18 1453 MS HTP None human HeLa cells 34846842 None
10023522 TSAVSSQANSQPPVQVSVK S 18 608 MS HTP None human HeLa cells 34846842 None
10023553 LQNYGELGPGTTGASSSGAGLHWGGPTQSSAYGK S 30 1465 MS HTP None human HeLa cells 34846842 None
10024545 1447 MS HTP None human colorectal cancer (CRC) cell lines 35254053 None
10024546 592 MS HTP None human colorectal cancer (CRC) cell lines 35254053 None
10024547 1363 MS HTP None human colorectal cancer (CRC) cell lines 35254053 None
10025323 TSAVSSQANSQPPVQVSVK T 1 592 MS HTP None human THP1 cells 32938750 None
10025324 TSAVSSQANSQPPVQVSVK S 2 593 MS HTP None human THP1 cells 32938750 None
10025325 TSAVSSQANSQPPVQVSVK S 6 597 MS HTP None human THP1 cells 32938750 None
10025526 TSAVSSQANSQPPVQVSVK T 592 MS HTP None human liver 31637018 None
10025527 TSAVSSQANSQPPVQVSVK S 608 MS HTP None human liver 31637018 None
10025528 TSAVSSQANSQPPVQVSVK S 593 MS HTP None human liver 31637018 None
10025529 TSAVSSQANSQPPVQVSVK S 601 MS HTP None human liver 31637018 None
10026438 TSAVSSQANSQPPVQVSVK S 10 601 MS HTP None human Jurkat cells, MCF-7 cells, K562 cells 35132862 None
10026439 TSAVSSQANSQPPVQVSVK S 6 597 MS HTP None human Jurkat cells, MCF-7 cells, K562 cells 35132862 None
10026703 TSAVSSQANSQPPVQVSVK S 2 593 MS HTP None human HeLa cells 35254053 None
10026704 TSAVSSQANSQPPVQVSVK T 1 592 MS HTP None human HeLa cells 35254053 None
10028276 TSAVSSQANSQPPVQVSVK S 6 597 MS HTP None human HeLa cells 35254053 None
10028462 TSAVSSQANSQPPVQVSVK S 5 596 MS HTP None human HeLa cells 35254053 None
10028463 NSGPALTESLVQTLVK T 7 1363 MS HTP None human HeLa cells 35254053 None
10028464 LQNYGELGPGTTGASSSGAGLHWGGPTQSSAYGK T 12 1448 MS HTP None human HeLa cells 35254053 None
10029767 TSAVSSQANSQPPVQVSVK T 1 592 MS HTP None human SW480 cells 35254053 None
10029768 TSAVSSQANSQPPVQVSVK S 2 593 MS HTP None human SW480 cells 35254053 None
10029769 TSAVSSQANSQPPVQVSVK S 6 597 MS HTP None human SW480 cells 35254053 None
10029770 LQNYGELGPGTTGASSSGAGLHWGGPTQSSAYGK T 11 1447 MS HTP None human SW480 cells 35254053 None
10030047 NSGPALTESLVQTLVK T 7 1363 MS HTP None human SW480 cells 35254053 None
10030827 TSAVSSQANSQPPVQVSVK T 1 592 MS HTP None human SW620 cells 35254053 None
10030828 TSAVSSQANSQPPVQVSVK S 2 593 MS HTP None human SW620 cells 35254053 None
10030829 TSAVSSQANSQPPVQVSVK S 6 597 MS HTP None human SW620 cells 35254053 None
10031196 NSGPALTESLVQTLVK T 7 1363 MS HTP None human SW620 cells 35254053 None
10031197 LQNYGELGPGTTGASSSGAGLHWGGPTQSSAYGK T 11 1447 MS HTP None human SW620 cells 35254053 None
10031999 T 1447 MS HTP None human SW480 cells, SW620 cells 35254053 None
10032000 T 592 MS HTP None human SW480 cells, SW620 cells 35254053 None
10032001 T 1363 MS HTP None human SW480 cells, SW620 cells 35254053 None
10032511 TSAVSSQANSQPPVQVSVK S 10 601 MS HTP None human HeLa cell nucleus 35289036 None
10032512 TSAVSSQANSQPPVQVSVK S 2 593 MS HTP None human HeLa cell nucleus 35289036 None
10032782 TSAVSSQANSQPPVQVSVK S 5 596 MS HTP None human HeLa cell nucleus 35289036 None
10032879 TSAVSSQANSQPPVQVSVK S 6 597 MS HTP None human HeLa cell nucleus 35289036 None
10033531 TSAVSSQANSQPPVQVSVK T 1 592 MS HTP None human HeLa cell nucleus 35289036 None
10033532 LQNYGELGPGTTGASSSGAGLHWGGPTQSSAYGK S 30 1466 MS HTP None human HeLa cell nucleus 35289036 None
10034512 LQNYGELGPGTTGASSSGAGLHWGGPTQSSAYGK T 1448 MS HTP None human MCF-7 cells 35513511 None
10034513 TSAVSSQANSQPPVQVSVK T 592 MS HTP None human MCF-7 cells 35513511 None
10034921 TSAVSSQANSQPPVQVSVK S 6 597 MS HTP None human Jurkat cells 35705054 None
10034922 TSAVSSQANSQPPVQVSVK S 10 601 MS HTP None human Jurkat cells 35705054 None
10035090 TSAVSSQANSQPPVQVSVK S 10 601 MS HTP None human Jurkat cells 35705054 None