Details for Accession #: Q8TEK3

Protein Sequence

>sp|Q8TEK3|DOT1L_HUMAN Histone-lysine N-methyltransferase, H3 lysine-79 specific OS=Homo sapiens OX=9606 GN=DOT1L PE=1 SV=3
MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVL
IDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSTGLLRHILQQVYNHSVT
DPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTDDDLFVDLGSGVGQVVLQVAAATNCK
HHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFV
NNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLK
GSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRESKSNAATPTKGP
EGKVAGPADAPMDSGAEEEKAGAATVKKPSPSKARKKKLNKKGRKMAGRKRGRPKKMNTA
NPERKPKKNQTALDALHAQTVSQTAASSPQDAYRSPHSPFYQLPPSVQRHSPNPLLVAPT
PPALQKLLESFKIQYLQFLAYTKTPQYKASLQELLGQEKEKNAQLLGAAQQLLSHCQAQK
EEIRRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQSEQLEQDNRALRGQSLQLL
KARCEELQLDWATLSLEKLLKEKQALKSQISEKQRHCLELQISIVELEKSQRQQELLQLK
SCVPPDDALSLHLRGKGALGRELEPDASRLHLELDCTKFSLPHLSSMSPELSMNGQAAGY
ELCGVLSRPSSKQNTPQYLASPLDQEVVPCTPSHVGRPRLEKLSGLAAPDYTRLSPAKIV
LRRHLSQDHTVPGRPAASELHSRAEHTKENGLPYQSPSVPGSMKLSPQDPRPLSPGALQL
AGEKSSEKGLRERAYGSSGELITSLPISIPLSTVQPNKLPVSIPLASVVLPSRAERARST
PSPVLQPRDPSSTLEKQIGANAHGAGSRSLALAPAGFSYAGSVAISGALAGSPASLTPGA
EPATLDESSSSGSLFATVGSRSSTPQHPLLLAQPRNSLPASPAHQLSSSPRLGGAAQGPL
PEASKGDLPSDSGFSDPESEAKRRIVFTITTGAGSAKQSPSSKHSPLTASARGDCVPSHG
QDSRRRGRRKRASAGTPSLSAGVSPKRRALPSVAGLFTQPSGSPLNLNSMVSNINQPLEI
TAISSPETSLKSSPVPYQDHDQPPVLKKERPLSQTNGAHYSPLTSDEEPGSEDEPSSARI
ERKIATISLESKSPPKTLENGGGLAGRKPAPAGEPVNSSKWKSTFSPISDIGLAKSADSP
LQASSALSQNSLFTFRPALEEPSADAKLAAHPRKGFPGSLSGADGLSPGTNPANGCTFGG
GLAADLSLHSFSDGASLPHKGPEAAGLSSPLSFPSQRGKEGSDANPFLSKRQLDGLAGLK
GEGSRGKEAGEGGLPLCGPTDKTPLLSGKAAKARDREVDLKNGHNLFISAAAVPPGSLLS
GPGLAPAASSAGGAASSAQTHRSFLGPFPPGPQFALGPMSLQANLGSVAGSSVLQSLFSS
VPAAAGLVHVSSAATRLTNSHAMGSFSGVAGGTVGGN

Peptide Information

ID Peptide Seq Site Residue Position in Peptide Position in Protein
10019777 1449
10022216 S 1511
10024150 882
10028209 NGHNLFISAAAVPPGSLLSGPGLAPAASSAGGAASSAQTHR S 28 1449
10030672 LPVSIPLASVVLPSR S 4 882
10031340 NGHNLFISAAAVPPGSLLSGPGLAPAASSAGGAASSAQTHR S 28 1449
10031630 S 882

O-GlcNAcylation Information

ID Method Analytical Throughput Ambiguity Species Sample Type Data Source PMID Comments
10019777 MS HTP None human HeLa cells 34161081 None
10022216 MS, site-specific mutagenesis LTP None human HEK 293T cells 34551297 None
10024150 MS HTP None human colorectal cancer (CRC) cell lines 35254053 None
10028209 MS HTP None human HeLa cells 35254053 None
10030672 MS HTP None human SW620 cells 35254053 None
10031340 MS HTP None human SW620 cells 35254053 None
10031630 MS HTP None human SW480 cells, SW620 cells 35254053 None
ID Peptide Seq Site Residue Position in Peptide Position in Protein Method Analytical Throughput Ambiguity Species Sample Type Data Source PMID Comments
10019777 1449 MS HTP None human HeLa cells 34161081 None
10022216 S 1511 MS, site-specific mutagenesis LTP None human HEK 293T cells 34551297 None
10024150 882 MS HTP None human colorectal cancer (CRC) cell lines 35254053 None
10028209 NGHNLFISAAAVPPGSLLSGPGLAPAASSAGGAASSAQTHR S 28 1449 MS HTP None human HeLa cells 35254053 None
10030672 LPVSIPLASVVLPSR S 4 882 MS HTP None human SW620 cells 35254053 None
10031340 NGHNLFISAAAVPPGSLLSGPGLAPAASSAGGAASSAQTHR S 28 1449 MS HTP None human SW620 cells 35254053 None
10031630 S 882 MS HTP None human SW480 cells, SW620 cells 35254053 None