O-GlcNAc Database

Details for Accession #: Q8NEZ4

Protein Sequence

>sp|Q8NEZ4|KMT2C_HUMAN Histone-lysine N-methyltransferase 2C OS=Homo sapiens OX=9606 GN=KMT2C PE=1 SV=3
MSSEEDKSVEQPQPPPPPPEEPGAPAPSPAAADKRPRGRPRKDGASPFQRARKKPRSRGK
TAVEDEDSMDGLETTETETIVETEIKEQSAEEDAEAEVDNSKQLIPTLQRSVSEESANSL
VSVGVEAKISEQLCAFCYCGEKSSLGQGDLKQFRITPGFILPWRNQPSNKKDIDDNSNGT
YEKMQNSAPRKQRGQRKERSPQQNIVSCVSVSTQTASDDQAGKLWDELSLVGLPDAIDIQ
ALFDSTGTCWAHHRCVEWSLGVCQMEEPLLVNVDKAVVSGSTERCAFCKHLGATIKCCEE
KCTQMYHYPCAAGAGTFQDFSHIFLLCPEHIDQAPERSKEDANCAVCDSPGDLLDQFFCT
TCGQHYHGMCLDIAVTPLKRAGWQCPECKVCQNCKQSGEDSKMLVCDTCDKGYHTFCLQP
VMKSVPTNGWKCKNCRICIECGTRSSSQWHHNCLICDNCYQQQDNLCPFCGKCYHPELQK
DMLHCNMCKRWVHLECDKPTDHELDTQLKEEYICMYCKHLGAEMDRLQPGEEVEIAELTT
DYNNEMEVEGPEDQMVFSEQAANKDVNGQESTPGIVPDAVQVHTEEQQKSHPSESLDTDS
LLIAVSSQHTVNTELEKQISNEVDSEDLKMSSEVKHICGEDQIEDKMEVTENIEVVTHQI
TVQQEQLQLLEEPETVVSREESRPPKLVMESVTLPLETLVSPHEESISLCPEEQLVIERL
QGEKEQKENSELSTGLMDSEMTPTIEGCVKDVSYQGGKSIKLSSETESSFSSSADISKAD
VSSSPTPSSDLPSHDMLHNYPSALSSSAGNIMPTTYISVTPKIGMGKPAITKRKFSPGRP
RSKQGAWSTHNTVSPPSWSPDISEGREIFKPRQLPGSAIWSIKVGRGSGFPGKRRPRGAG
LSGRGGRGRSKLKSGIGAVVLPGVSTADISSNKDDEENSMHNTVVLFSSSDKFTLNQDMC
VVCGSFGQGAEGRLLACSQCGQCYHPYCVSIKITKVVLSKGWRCLECTVCEACGKATDPG
RLLLCDDCDISYHTYCLDPPLQTVPKGGWKCKWCVWCRHCGATSAGLRCEWQNNYTQCAP
CASLSSCPVCYRNYREEDLILQCRQCDRWMHAVCQNLNTEEEVENVADIGFDCSMCRPYM
PASNVPSSDCCESSLVAQIVTKVKELDPPKTYTQDGVCLTESGMTQLQSLTVTVPRRKRS
KPKLKLKIINQNSVAVLQTPPDIQSEHSRDGEMDDSREGELMDCDGKSESSPEREAVDDE
TKGVEGTDGVKKRKRKPYRPGIGGFMVRQRSRTGQGKTKRSVIRKDSSGSISEQLPCRDD
GWSEQLPDTLVDESVSVTESTEKIKKRYRKRKNKLEETFPAYLQEAFFGKDLLDTSRQSK
ISLDNLSEDGAQLLYKTNMNTGFLDPSLDPLLSSSSAPTKSGTHGPADDPLADISEVLNT
DDDILGIISDDLAKSVDHSDIGPVTDDPSSLPQPNVNQSSRPLSEEQLDGILSPELDKMV
TDGAILGKLYKIPELGGKDVEDLFTAVLSPANTQPTPLPQPPPPTQLLPIHNQDAFSRMP
LMNGLIGSSPHLPHNSLPPGSGLGTFSAIAQSSYPDARDKNSAFNPMASDPNNSWTSSAP
TVEGENDTMSNAQRSTLKWEKEEALGEMATVAPVLYTNINFPNLKEEFPDWTTRVKQIAK
LWRKASSQERAPYVQKARDNRAALRINKVQMSNDSMKRQQQQDSIDPSSRIDSELFKDPL
KQRESEHEQEWKFRQQMRQKSKQQAKIEATQKLEQVKNEQQQQQQQQFGSQHLLVQSGSD
TPSSGIQSPLTPQPGNGNMSPAQSFHKELFTKQPPSTPTSTSSDDVFVKPQAPPPPPAPS
RIPIQDSLSQAQTSQPPSPQVFSPGSSNSRPPSPMDPYAKMVGTPRPPPVGHSFSRRNSA
APVENCTPLSSVSRPLQMNETTANRPSPVRDLCSSSTTNNDPYAKPPDTPRPVMTDQFPK
SLGLSRSPVVSEQTAKGPIAAGTSDHFTKPSPRADVFQRQRIPDSYARPLLTPAPLDSGP
GPFKTPMQPPPSSQDPYGSVSQASRRLSVDPYERPALTPRPIDNFSHNQSNDPYSQPPLT
PHPAVNESFAHPSRAFSQPGTISRPTSQDPYSQPPGTPRPVVDSYSQSSGTARSNTDPYS
QPPGTPRPTTVDPYSQQPQTPRPSTQTDLFVTPVTNQRHSDPYAHPPGTPRPGISVPYSQ
PPATPRPRISEGFTRSSMTRPVLMPNQDPFLQAAQNRGPALPGPLVRPPDTCSQTPRPPG
PGLSDTFSRVSPSAARDPYDQSPMTPRSQSDSFGTSQTAHDVADQPRPGSEGSFCASSNS
PMHSQGQQFSGVSQLPGPVPTSGVTDTQNTVNMAQADTEKLRQRQKLREIILQQQQQKKI
AGRQEKGSQDSPAVPHPGPLQHWQPENVNQAFTRPPPPYPGNIRSPVAPPLGPRYAVFPK
DQRGPYPPDVASMGMRPHGFRFGFPGGSHGTMPSQERFLVPPQQIQGSGVSPQLRRSVSV
DMPRPLNNSQMNNPVGLPQHFSPQSLPVQQHNILGQAYIELRHRAPDGRQRLPFSAPPGS
VVEASSNLRHGNFIPRPDFPGPRHTDPMRRPPQGLPNQLPVHPDLEQVPPSQQEQGHSVH
SSSMVMRTLNHPLGGEFSEAPLSTSVPSETTSDNLQITTQPSDGLEEKLDSDDPSVKELD
VKDLEGVEVKDLDDEDLENLNLDTEDGKVVELDTLDNLETNDPNLDDLLRSGEFDIIAYT
DPELDMGDKKSMFNEELDLPIDDKLDNQCVSVEPKKKEQENKTLVLSDKHSPQKKSTVTN
EVKTEVLSPNSKVESKCETEKNDENKDNVDTPCSQASAHSDLNDGEKTSLHPCDPDLFEK
RTNRETAGPSANVIQASTQLPAQDVINSCGITGSTPVLSSLLANEKSDNSDIRPSGSPPP
PTLPASPSNHVSSLPPFIAPPGRVLDNAMNSNVTVVSRVNHVFSQGVQVNPGLIPGQSTV
NHSLGTGKPATQTGPQTSQSGTSSMSGPQQLMIPQTLAQQNRERPLLLEEQPLLLQDLLD
QERQEQQQQRQMQAMIRQRSEPFFPNIDFDAITDPIMKAKMVALKGINKVMAQNNLGMPP
MVMSRFPFMGQVVTGTQNSEGQNLGPQAIPQDGSITHQISRPNPPNFGPGFVNDSQRKQY
EEWLQETQQLLQMQQKYLEEQIGAHRKSKKALSAKQRTAKKAGREFPEEDAEQLKHVTEQ
QSMVQKQLEQIRKQQKEHAELIEDYRIKQQQQCAMAPPTMMPSVQPQPPLIPGATPPTMS
QPTFPMVPQQLQHQQHTTVISGHTSPVRMPSLPGWQPNSAPAHLPLNPPRIQPPIAQLPI
KTCTPAPGTVSNANPQSGPPPRVEFDDNNPFSESFQERERKERLREQQERQRIQLMQEVD
RQRALQQRMEMEQHGMVGSEISSSRTSVSQIPFYSSDLPCDFMQPLGPLQQSPQHQQQMG
QVLQQQNIQQGSINSPSTQTFMQTNERRQVGPPSFVPDSPSIPVGSPNFSSVKQGHGNLS
GTSFQQSPVRPSFTPALPAAPPVANSSLPCGQDSTITHGHSYPGSTQSLIQLYSDIIPEE
KGKKKRTRKKKRDDDAESTKAPSTPHSDITAPPTPGISETTSTPAVSTPSELPQQADQES
VEPVGPSTPNMAAGQLCTELENKLPNSDFSQATPNQQTYANSEVDKLSMETPAKTEEIKL
EKAETESCPGQEEPKLEEQNGSKVEGNAVACPVSSAQSPPHSAGAPAAKGDSGNELLKHL
LKNKKSSSLLNQKPEGSICSEDDCTKDNKLVEKQNPAEGLQTLGAQMQGGFGCGNQLPKT
DGGSETKKQRSKRTQRTGEKAAPRSKKRKKDEEEKQAMYSSTDTFTHLKQQNNLSNPPTP
PASLPPTPPPMACQKMANGFATTEELAGKAGVLVSHEVTKTLGPKPFQLPFRPQDDLLAR
ALAQGPKTVDVPASLPTPPHNNQEELRIQDHCGDRDTPDSFVPSSSPESVVGVEVSRYPD
LSLVKEEPPEPVPSPIIPILPSTAGKSSESRRNDIKTEPGTLYFASPFGPSPNGPRSGLI
SVAITLHPTAAENISSVVAAFSDLLHVRIPNSYEVSSAPDVPSMGLVSSHRINPGLEYRQ
HLLLRGPPPGSANPPRLVSSYRLKQPNVPFPPTSNGLSGYKDSSHGIAESAALRPQWCCH
CKVVILGSGVRKSFKDLTLLNKDSRESTKRVEKDIVFCSNNCFILYSSTAQAKNSENKES
IPSLPQSPMRETPSKAFHQYSNNISTLDVHCLPQLPEKASPPASPPIAFPPAFEAAQVEA
KPDELKVTVKLKPRLRAVHGGFEDCRPLNKKWRGMKWKKWSIHIVIPKGTFKPPCEDEID
EFLKKLGTSLKPDPVPKDYRKCCFCHEEGDGLTDGPARLLNLDLDLWVHLNCALWSTEVY
ETQAGALINVELALRRGLQMKCVFCHKTGATSGCHRFRCTNIYHFTCAIKAQCMFFKDKT
MLCPMHKPKGIHEQELSYFAVFRRVYVQRDEVRQIASIVQRGERDHTFRVGSLIFHTIGQ
LLPQQMQAFHSPKALFPVGYEASRLYWSTRYANRRCRYLCSIEEKDGRPVFVIRIVEQGH
EDLVLSDISPKGVWDKILEPVACVRKKSEMLQLFPAYLKGEDLFGLTVSAVARIAESLPG
VEACENYTFRYGRNPLMELPLAVNPTGCARSEPKMSAHVKRFVLRPHTLNSTSTSKSFQS
TVTGELNAPYSKQFVHSKSSQYRKMKTEWKSNVYLARSRIQGLGLYAARDIEKHTMVIEY
IGTIIRNEVANRKEKLYESQNRGVYMFRMDNDHVIDATLTGGPARYINHSCAPNCVAEVV
TFERGHKIIISSSRRIQKGEELCYDYKFDFEDDQHKIPCHCGAVNCRKWMN

Peptide Information

ID	Peptide Seq	Site Residue	Position in Peptide	Position in Protein
1088	DLLDTSR	T	5	1375.0
10006255	SAARDPYDQSPMTPRSQSDSFGTSQTAHDVA	S		2308
10006256	SVPYSQPPATPRPRISEGFTRSSMTRPVLMP	S		2230
10008094	RQQQQDSIDPSSR	S		1728
10008095	RQQQQDSIDPSSR	S		1729
10008096	PSPRADVFQR	S		2011
10008097	TEVLSPNSK	S		2831
10008098	RQQQQDSIDPSSR	S		1724
10009068	ISEGFTR	S	2	2230
10011200	ISEGFTR	S	2	2230
10011999	ISEGFTR	T	6	2234
10016914	ISEGFTR	S	2	2230
10019697				1840
10022008				1840
10025167	QPPSTPTSTSSDDVFVKPQAPPPPPAPSR	T	5	1837
10025168	QPPSTPTSTSSDDVFVKPQAPPPPPAPSR	S	8	1840
10026281	QPPSTPTSTSSDDVFVKPQAPPPPPAPSR	S	11	1843
10027559	ISEGFTR	S	2	2230
10028415	QPPSTPTSTSSDDVFVKPQAPPPPPAPSR	S	8	1840
10030177	PGISVPYSQPPATPR	S	4	2215
10030662	ISEGFTR	S	2	2230
10030663	SQSDSFGTSQTAHDVADQPR	S	1	2308
10031334	QPPSTPTSTSSDDVFVKPQAPPPPPAPSR	S	8	1840

O-GlcNAcylation Information

ID	Method	Analytical Throughput	Ambiguity	Species	Sample Type	Data Source PMID	Comments
1088	MS	HTP	None	human	HEK 293 cells	23301498	None
10006255	MS	HTP	None	human	HeLa cells	30059200	None
10006256	MS	HTP	None	human	HeLa cells	30059200	None
10008094	MS	HTP	None	human	HeLa cells	30379171	None
10008095	MS	HTP	None	human	HeLa cells	30379171	None
10008096	MS	HTP	None	human	HeLa cells	30379171	None
10008097	MS	HTP	None	human	HeLa cells	30379171	None
10008098	MS	HTP	None	human	HeLa cells	30379171	None
10009068	MS	HTP	None	human	HEK 293T cells	30620550	None
10011200	MS	HTP	None	human	HeLa cells	31492838	None
10011999	MS	HTP	None	human	MCF-7 cells	32574038	None
10016914	MS	HTP	None	human	HeLa cells	30059200	None
10019697	MS	HTP	None	human	HeLa cells	34161081	None
10022008	MS	HTP	None	human	HeLa cells	34161081	None
10025167	MS	HTP	None	human	THP1 cells	32938750	None
10025168	MS	HTP	None	human	THP1 cells	32938750	None
10026281	MS	HTP	None	human	Jurkat cells, MCF-7 cells, K562 cells	35132862	None
10027559	MS	HTP	None	human	HeLa cells	35254053	None
10028415	MS	HTP	None	human	HeLa cells	35254053	None
10030177	MS	HTP	None	human	SW480 cells	35254053	None
10030662	MS	HTP	None	human	SW620 cells	35254053	None
10030663	MS	HTP	None	human	SW620 cells	35254053	None
10031334	MS	HTP	None	human	SW620 cells	35254053	None

ID	Peptide Seq	Site Residue	Position in Peptide	Position in Protein	Method	Analytical Throughput	Ambiguity	Species	Sample Type	Data Source PMID	Comments
1088	DLLDTSR	T	5	1375.0	MS	HTP	None	human	HEK 293 cells	23301498	None
10006255	SAARDPYDQSPMTPRSQSDSFGTSQTAHDVA	S		2308	MS	HTP	None	human	HeLa cells	30059200	None
10006256	SVPYSQPPATPRPRISEGFTRSSMTRPVLMP	S		2230	MS	HTP	None	human	HeLa cells	30059200	None
10008094	RQQQQDSIDPSSR	S		1728	MS	HTP	None	human	HeLa cells	30379171	None
10008095	RQQQQDSIDPSSR	S		1729	MS	HTP	None	human	HeLa cells	30379171	None
10008096	PSPRADVFQR	S		2011	MS	HTP	None	human	HeLa cells	30379171	None
10008097	TEVLSPNSK	S		2831	MS	HTP	None	human	HeLa cells	30379171	None
10008098	RQQQQDSIDPSSR	S		1724	MS	HTP	None	human	HeLa cells	30379171	None
10009068	ISEGFTR	S	2	2230	MS	HTP	None	human	HEK 293T cells	30620550	None
10011200	ISEGFTR	S	2	2230	MS	HTP	None	human	HeLa cells	31492838	None
10011999	ISEGFTR	T	6	2234	MS	HTP	None	human	MCF-7 cells	32574038	None
10016914	ISEGFTR	S	2	2230	MS	HTP	None	human	HeLa cells	30059200	None
10019697				1840	MS	HTP	None	human	HeLa cells	34161081	None
10022008				1840	MS	HTP	None	human	HeLa cells	34161081	None
10025167	QPPSTPTSTSSDDVFVKPQAPPPPPAPSR	T	5	1837	MS	HTP	None	human	THP1 cells	32938750	None
10025168	QPPSTPTSTSSDDVFVKPQAPPPPPAPSR	S	8	1840	MS	HTP	None	human	THP1 cells	32938750	None
10026281	QPPSTPTSTSSDDVFVKPQAPPPPPAPSR	S	11	1843	MS	HTP	None	human	Jurkat cells, MCF-7 cells, K562 cells	35132862	None
10027559	ISEGFTR	S	2	2230	MS	HTP	None	human	HeLa cells	35254053	None
10028415	QPPSTPTSTSSDDVFVKPQAPPPPPAPSR	S	8	1840	MS	HTP	None	human	HeLa cells	35254053	None
10030177	PGISVPYSQPPATPR	S	4	2215	MS	HTP	None	human	SW480 cells	35254053	None
10030662	ISEGFTR	S	2	2230	MS	HTP	None	human	SW620 cells	35254053	None
10030663	SQSDSFGTSQTAHDVADQPR	S	1	2308	MS	HTP	None	human	SW620 cells	35254053	None
10031334	QPPSTPTSTSSDDVFVKPQAPPPPPAPSR	S	8	1840	MS	HTP	None	human	SW620 cells	35254053	None